Ionic Cross Talk Can Lead to Overestimation of 3-Methoxytyramine during Quantification of Metanephrines by Mass Spectrometry
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چکیده
منابع مشابه
Ionic cross talk can lead to overestimation of 3-methoxytyramine during quantification of metanephrines by mass spectrometry.
Measurements of urine or plasma metanephrine (MN) and normetanephrine (NMN) are considered pivotal tests in the diagnosis of pheochromocytoma and paraganglioma. There has also been increasing interest in measuring 3-methoxytyramine (3MT), the corresponding Omethylated metabolite of dopamine. 3MT measurement might allow earlier diagnosis of rare cases of pheochromocytoma and paraganglioma that s...
متن کاملReferences Joop Ten Kate 3 Ionic Cross Talk Can Lead to Overestimation of 3-methoxytyramine during Quantification of Metanephrines by Mass Spectrometry
sample extraction further improved the accuracy of the 2 second generation assays in the low range (Table 1; also see online Supplemental Data Fig. 1), which indicates that they still suffer from interfering compounds and their specificity can be further improved. For several immunoassays an increased bias was observed (Table 1); this finding could be explained by the design of the assay, which...
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متن کاملIsopropanol protein precipitation for the analysis of plasma free metanephrines by liquid chromatography-tandem mass spectrometry.
BACKGROUND High-performance liquid chromatography-tandem mass spectrometric (LC-MS/MS)1 analysis of plasma free metanephrines is the most diagnostically sensitive and specific screening test for the diagnosis of pheochromocytoma. We sought to develop an in-house method for this expensive test METHODS We used off-line isopropanol protein precipitation of plasma to remove interfering substances...
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ژورنال
عنوان ژورنال: Clinical Chemistry
سال: 2012
ISSN: 0009-9147,1530-8561
DOI: 10.1373/clinchem.2012.186601